Certepetide
Product Sizes
5 mg
£ POA
HY-P3448-5MG
10 mg
£ POA
HY-P3448-10MG
About this Product
- SKU:
- HY-P3448
- Additional Names:
- CEND-1; iRGD; LSTA1
- Application:
- Antibody Microarray
- CAS Number:
- 2580154-02-3
- Extra Details:
- Certepetide (CEND-1) is a bifunctional cyclic peptide (a.k.a. iRGD). Certepetide is a tumor-penetrating enhancer via RGD motif interaction with alphav-integrins and via activating NRP-1; and transforms the solid tumor microenvironment into a temporary agent conduit. Certepetide accumulates in tumors; and is used in the research of pancreatic cancer and other solid tumors[1][2][3].
- Molecular Weight:
- 989.09
- Purity:
- 99.80
- References:
- [1]International Nonproprietary Names for Pharmaceutical Substances (INN). WHO Drug Information, Vol. 36, No. 2, 2022 |[2]Ruoslahti Erkki, et al. Methods for treating pancreatic cancer and other solid tumors. WO2021226148.|[3]Andrew Peter Dean, et al. Updated single institution outcome data from the first-in-human CEND-1 trial in metastatic pancreatic cancer. Journal of Clinical Oncology 2021 39:15_suppl, e16274-e16274|[4]Harri A Järveläinen, et al. Assessment of the Pharmacokinetics, Disposition, and Duration of Action of the Tumour-Targeting Peptide CEND-1. Int J Mol Sci. 2023 Mar 16;24(6):5700.|[5]Schmithals, C, et al. Improving Drug Penetrability with iRGD Leverages the Therapeutic Response to Sorafenib and Doxorubicin in Hepatocellular Carcinoma. Cancer Res. 2015 Aug 1;75(15):3147-54.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -80[o]C; 2 years; -20[o]C; 1 year (Powder; sealed storage; away from moisture and light; under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Pathway:
- Cytoskeleton;Immunology/Inflammation
