Ac-YVAD-AFC
Product Sizes
1 mg
£ POA
HY-P2377-1MG
5 mg
£ POA
HY-P2377-5MG
10 mg
£ POA
HY-P2377-10MG
About this Product
- SKU:
- HY-P2377
- CAS Number:
- 219137-85-6
- Extra Details:
- Ac-YVAD-AFC is a specifically designed fluorescent Caspase-1 substrate. Ac-YVAD-AFC can be specifically cleaved by activated Caspase-1; thereby releasing free AFC fluorophore for detection. Ac-YVAD-AFC is a powerful tool for quantitative analysis of enzyme activity; for example; playing a key role in studying TNF-α-induced Caspase-1 activation in adipocyte lysates. Ac-YVAD-AFC is widely used in mechanistic studies of inflammasome signaling pathways and related diseases such as sepsis[1][2].
- Molecular Weight:
- 719.66
- Purity:
- 99.90
- References:
- [1]Furuoka M, et al. TNF-α Induces Caspase-1 Activation Independently of Simultaneously Induced NLRP3 in 3T3-L1 Cells. J Cell Physiol. 2016 Dec;231(12):2761-7.|[2]Guo RF, et al. Protective effects of anti-C5a in sepsis-induced thymocyte apoptosis. J Clin Invest. 2000 Nov;106(10):1271-80.
- Research Area:
- Others
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -80[o]C; 2 years; -20[o]C; 1 year (Powder; sealed storage; away from moisture and light; under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores
- Pathway:
- Others
