Angstrom6
Product Sizes
10 mg
£ POA
HY-P2230-10MG
5 mg
£ POA
HY-P2230-5MG
About this Product
- SKU:
- HY-P2230
- Additional Names:
- A6 Peptide
- CAS Number:
- 220334-14-5
- Extra Details:
- Angstrom6 (A6 Peptide) is an 8 amino-acid peptide derived from single-chain urokinase plasminogen activator (scuPA) and interferes with the uPA/uPAR cascade and abrogates downstream effects. Angstrom6 binds to CD44 resulting in the inhibition of migration; invasion; and metastasis of tumor cells; and the modulation of CD44-mediated cell signaling[1][2].
- Molecular Weight:
- 910.97
- Purity:
- 99.98
- References:
- [1]Ghamande SA, et al. A phase 2, randomized, double-blind, placebo-controlled trial of clinical activity and safety of subcutaneous A6 in women with asymptomatic CA125 progression after first-line chemotherapy of epithelial ovarian cancer. Gynecol Oncol. 2008;111(1):89-94.|[2]Finlayson M. Modulation of CD44 Activity by A6-Peptide. Front Immunol. 2015;6:135. Published 2015 Mar 30.|[3]Piotrowicz RS, et al. A6 peptide activates CD44 adhesive activity, induces FAK and MEK phosphorylation, and inhibits the migration and metastasis of CD44-expressing cells. Mol Cancer Ther. 2011;10(11):2072-2082.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -80[o]C; 2 years; -20[o]C; 1 year (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Pathway:
- Metabolic Enzyme/Protease
