CLP-d2
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HY-P11617-1EACH
About this Product
- SKU:
- HY-P11617
- Extra Details:
- CLP-d2 is a multi-target anti-inflammatory agent; osteoclastogenesis inhibitor and immunomodulator with superior pharmacokinetic properties to Daptomycin (HY-B0108) and good safety profiles. CLP-d2 inhibits the NF-κB and MAPK signaling pathways by reducing the expression levels of c-Fos and NFATc1; and decreasing the phosphorylation levels of IκBα; p65; ERK and JNK; thereby reducing the secretion of pro-inflammatory cytokines such as IL-6; TNF-α and IL-1β to exert anti-inflammatory activity. CLP-d2 inhibits intra-articular osteoclastogenesis in mice; alleviates bone erosion and joint swelling; reduces synovial hyperplasia and inflammatory cell infiltration; and decreases serum rheumatoid factor (RF) levels. CLP-d2 is applicable to related research on rheumatoid arthritis[1].
- Molecular Weight:
- 1725.76
- Research Area:
- Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
