Astressin 2B (TFA)
Product Sizes
1 mg
£ POA
HY-P1108A-1MG
10 mg
£ POA
HY-P1108A-10MG
5 mg
£ POA
HY-P1108A-5MG
500 μg
£ POA
HY-P1108A-500UG
About this Product
- SKU:
- HY-P1108A
- Extra Details:
- Astressin 2B TFA is a blood-brain barrier-impermeable; highly selective CRFR2 antagonist (rCRFR2; IC50=0.57 nM). Astressin 2B TFA blocks the protective effects mediated by CRFR2; thereby exacerbating indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B TFA reverses the protective effects of Urocortin 1 against intestinal hypermotility; bacterial invasion and upregulation of inflammatory mediators. Astressin 2B TFA also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In the Clostridioides difficile toxin A (C. difficile toxin A)-mediated enteritis model; Astressin 2B TFA mimics the phenotype of CRFR2-deficient mice; significantly exacerbating intestinal epithelial damage; edema; neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B TFA is an important tool molecule for investigating the intestinal protective mechanisms of CRFR2[1][2][3][4][5][6][7].
- Molecular Weight:
- 4041.69 (free base)
- Purity:
- 99.54
- References:
- [1]Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747.|[2]Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.|[3]Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470.
- Research Area:
- Inflammation/Immunology;Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -80[o]C; 2 years; -20[o]C; 1 year (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Pathway:
- Membrane Transporter/Ion Channel
