Astressin 2B
Product Sizes
1 mg
£ POA
HY-P1108-1MG
5 mg
£ POA
HY-P1108-5MG
10 mg
£ POA
HY-P1108-10MG
500 μg
£ POA
HY-P1108-500UG
About this Product
- SKU:
- HY-P1108
- CAS Number:
- 681260-70-8
- Extra Details:
- Astressin 2B is a blood-brain barrier-impermeable; highly selective CRFR2 antagonist (rCRF2; IC50 = 0.57 nM). Astressin 2B blocks the protective effects mediated by CRFR2; thereby exacerbating Indomethacin (HY-14397)-induced hemorrhagic intestinal injury in rats. Astressin 2B reverses the protective effects of Urocortin 1 against intestinal hypermotility; bacterial invasion and upregulation of inflammatory mediators. Astressin 2B also blocks the anxiogenic effect of Urocortin 2 and attenuates stress-induced anxiety-related behaviors. In a C. difficile toxin A-mediated enteritis model; Astressin 2B mimics the phenotype of CRFR2-deficient mice; significantly exacerbating intestinal epithelial damage; edema; neutrophil migration and the expression of multiple proinflammatory cytokines. Astressin 2B is a valuable tool molecule for investigating the intestinal protective mechanisms of CRFR2[1][2][3][4][5][6][7].
- Molecular Weight:
- 4041.69
- Purity:
- 97.81
- References:
- [1]Rivier J, et al. Potent and long-acting corticotropin releasing factor (CRF) receptor 2 selective peptide competitive antagonists. J Med Chem. 2002;45(21):4737-4747.|[2]Henry B, et al. The effect of lateral septum corticotropin-releasing factor receptor 2 activation on anxiety is modulated by stress. J Neurosci. 2006;26(36):9142-9152.|[3]Hoare SR, et al. Peptide ligand binding properties of the corticotropin-releasing factor (CRF) type 2 receptor: pharmacology of endogenously expressed receptors, G-protein-coupling sensitivity and determinants of CRF2 receptor selectivity. Peptides. 2005;26(3):457-470.
- Research Area:
- Inflammation/Immunology;Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -80[o]C; 2 years; -20[o]C; 1 year (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
