COG 133
Product Sizes
1 mg
£ POA
HY-P1050-1MG
5 mg
£ POA
HY-P1050-5MG
10 mg
£ POA
HY-P1050-10MG
About this Product
- SKU:
- HY-P1050
- CAS Number:
- 514200-66-9
- Extra Details:
- COG 133 is a fragment of Apolipoprotein E (APOE) peptide. COG 133 competes with the ApoE holoprotein for binding the LDL receptor; with potent anti-inflammatory and neuroprotective effects. COG 133 is also a nAChR antagonist with an IC50 of 445 nM[1][2].
- Molecular Weight:
- 2169.71
- Purity:
- 98.72
- References:
- [1]Orleâncio Gomes R Azevedo, et al. Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. BMC Gastroenterol. 2012 Jul 13;12:35.|[2]Elaine A Gay, et al. Apolipoprotein E-derived peptides block alpha7 neuronal nicotinic acetylcholine receptors expressed in xenopus oocytes. J Pharmacol Exp Ther. 2006 Feb;316(2):835-42.|[3]Huachun Cui, et al. Monocyte-derived alveolar macrophage apolipoprotein E participates in pulmonary fibrosis resolution. JCI Insight. 2020 Mar 12;5(5):e134539.
- Research Area:
- Inflammation/Immunology; Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -80[o]C; 2 years; -20[o]C; 1 year (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Pathway:
- Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
