Z-WEHD-FMK
Product Sizes
1 mg
£ POA
HY-P0111-1MG
25 mg
£ POA
HY-P0111-25MG
5 mg
£ POA
HY-P0111-5MG
10 mg
£ POA
HY-P0111-10MG
About this Product
- SKU:
- HY-P0111
- Additional Names:
- Z-WE(OMe)HD(OMe)-FMK
- CAS Number:
- 210345-00-9
- Extra Details:
- Z-WEHD-FMK is a potent; cell-permeable and irreversible caspase-1/5 inhibitor. Z-WEHD-FMK also exhibits a robust inhibitory effect on cathepsin B activity (IC50=6 μM). Z-WEHD-FMK can be used to investigate cells for evidence of apoptosis[1][2][4].
- Molecular Weight:
- 763.77
- Purity:
- 98.0
- References:
- [1]Kamada S, et al. Caspase-4 and caspase-5, members of the ICE/CED-3 family of cysteine proteases, are CrmA-inhibitable proteases.Cell Death Differ. 1997 Aug;4(6):473-8.|[2]Yang D, et al. Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish.Nat Commun. 2018 Aug 3;9(1):3052.|[3]Ferko MA, et al. Effects of metal ions on caspase-1 activation and interleukin-1β release in murine bone marrow-derived macrophages.PLoS One. 2018 Aug 23;13(8):e0199936.|[4]Newman ZL, et al. CA-074Me protection against anthrax lethal toxin.Infect Immun. 2009 Oct;77(10):4327-36.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -80[o]C; 2 years; -20[o]C; 1 year (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Pathway:
- Apoptosis;Metabolic Enzyme/Protease
