Apicidin
Product Sizes
5 mg
£ POA
HY-N6735-5MG
1 mg
£ POA
HY-N6735-1MG
10mM/1mL
£ POA
HY-N6735-10MM
About this Product
- SKU:
- HY-N6735
- Additional Names:
- OSI 2040
- Application:
- Antibody Microarray
- CAS Number:
- 183506-66-3
- Extra Details:
- Apicidin (OSI 2040) is a fungal metabolite; acts as an orally active histone deacetylase 7/8 (HDAC7/8) inhibitor; with antiparasitic activity and a broad spectrum antiproliferative activity. Apicidin can be used for cancer research[1][2][3][4].
- Molecular Weight:
- 623.78
- Purity:
- 99.87
- References:
- [1]Han JW, et al. Apicidin, a histone deacetylase inhibitor, inhibits proliferation of tumor cells via induction of p21WAF1/Cip1 and gelsolin. Cancer Res. 2000 Nov 1;60(21):6068-74.|[2]S J Darkin-Rattray, et al. Apicidin: a novel antiprotozoal agent that inhibits parasite histone deacetylase. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):13143-7.|[3]Beom Soo Shin, et al. Quantitative determination of absorption and first-pass metabolism of apicidin, a potent histone deacetylase inhibitor. Drug Metab Dispos. 2014 Jun;42(6):974-82.|[4]Ahn MY, et al. HDAC inhibitor apicidin suppresses murine oral squamous cell carcinoma cell growth in vitro and in vivo via inhibiting HDAC8 expression. Oncol Lett. 2018 Nov;16(5):6552-6560.
- Research Area:
- Cancer; Infection
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection;Cell Cycle/DNA Damage;Epigenetics
