Halofuginone
Product Sizes
25 mg
£ POA
HY-N1584-25MG
5 mg
£ POA
HY-N1584-5MG
50 mg
£ POA
HY-N1584-50MG
10 mg
£ POA
HY-N1584-10MG
100 mg
£ POA
HY-N1584-100MG
About this Product
- SKU:
- HY-N1584
- Additional Names:
- RU-19110
- CAS Number:
- 55837-20-2
- Extra Details:
- Halofuginone (RU-19110); a Febrifugine derivative; is a competitive prolyl-tRNA synthetase inhibitor with a Ki of 18.3 nM[1][2]. Halofuginone is a specific inhibitor of type-I collagen synthesis and attenuates osteoarthritis (OA) by inhibition of TGF-β activity[3][4]. Halofuginone is also a potent pulmonary vasodilator by activating Kv channels and blocking voltage-gated; receptor-operated and store-operated Ca2+ channels. Halofuginone has anti-malaria; anti-inflammatory; anti-cancer; anti-fibrosis effects[5].
- Molecular Weight:
- 414.68
- Purity:
- 99.28
- References:
- [1]Tsuchida K, et al. Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation. Free Radic Biol Med. 2017 Feb;103:236-247.|[2]Keller TL, et al. Halofuginone and other Febrifugine derivatives inhibit prolyl-tRNA synthetase. Nat Chem Biol. 2012 Feb 12;8(3):311-7.|[3]Cui Z, et al. Halofuginone attenuates osteoarthritis by inhibition of TGF-β activity and H-type vessel formation in subchondral bone. Ann Rheum Dis. 2016 Sep;75(9):1714-21.|[4]Tracy L McGaha, et al. Halofuginone, an inhibitor of type-I collagen synthesis and skin sclerosis, blocks transforming-growth-factor-beta-mediated Smad3 activation in fibroblasts. J Invest Dermatol. 2002 Mar;118(3):461-70.|[5]Pritesh P Jain, et al. Halofuginone, a Promising Drug for Treatment of Pulmonary Hypertension. Br J Pharmacol. 2021 Mar 10.
- Research Area:
- Cancer; Infection; Inflammation/Immunology; Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection;Cell Cycle/DNA Damage;Membrane Transporter/Ion Channel;Neuronal Signaling;Stem Cell/Wnt;TGF-beta/Smad
