1-Benzyl-I3C
Product Sizes
1 mg
£ POA
HY-N10159-1MG
5 mg
£ POA
HY-N10159-5MG
10 mg
£ POA
HY-N10159-10MG
10mM/1mL
£ POA
HY-N10159-10MM
About this Product
- SKU:
- HY-N10159
- Application:
- Antibody Microarray
- CAS Number:
- 60941-76-6
- Extra Details:
- 1-Benzyl-I3C is a NEDD4-1 inhibitor with significant anticancer activity. 1-Benzyl-I3C can directly inhibit the ubiquitination activity of NEDD4-1 with an IC50 of 12.3μM; which is significantly better than its precursor compound I3C of 284μM. 1-Benzyl-I3C and its analogs showed good effects in inhibiting the proliferation of human melanoma cells; which is roughly related to their potency as NEDD4-1 enzyme inhibitors. By combining in vitro ubiquitination experiments and thermal stability analysis; 1-Benzyl-I3C was shown to be able to bind to the catalytic HECT domain of NEDD4-1[1].
- Molecular Weight:
- 237.30
- Purity:
- 99.68
- References:
- [1]Indole-3-carbinol (I3C) analogues are potent small molecule inhibitors of NEDD4-1 ubiquitin ligase activity that disrupt proliferation of human melanoma cells
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
