(S)-Indoximod
Product Sizes
100 mg
£ POA
HY-N0707-100MG
500 mg
£ POA
HY-N0707-500MG
About this Product
- SKU:
- HY-N0707
- Additional Names:
- 1-Methyl-L-tryptophan; (S)-NLG-8189
- Application:
- Antibody Microarray
- CAS Number:
- 21339-55-9
- Extra Details:
- (S)-Indoximod (1-Methyl-L-tryptophan) is an inhibitor of indoleamine 2;3-dioxygenase (IDO) (Ki: 19 μM). (S)-Indoximod can be used for the research of cancer and neurological disease[1][2][3][4].
- Molecular Weight:
- 218.26
- Purity:
- 99.52
- References:
- [1]Huang GL, et, al. PEG-Poly(1-Methyl-l-Tryptophan)-Based Polymeric Micelles as Enzymatically Activated Inhibitors of Indoleamine 2,3-Dioxygenase. Nanomaterials (Basel). 2019 May 9;9(5):719.|[2]Liu X, et, al. 1-L-MT, an IDO inhibitor, prevented colitis-associated cancer by inducing CDC20 inhibition-mediated mitotic death of colon cancer cells. Int J Cancer. 2018 Sep 15;143(6):1516-1529.|[3]Rana P, et al. Comparison of fluoxetine and 1-methyl-L-tryptophan in treatment of depression-like illness in Bacillus Calmette-Guerin-induced inflammatory model of depression in mice. J Basic Clin Physiol Pharmacol. 2016 Nov 1;27(6):569-576. |[4]Čepcová D, et al. The protective effect of 1-methyltryptophan isomers in renal ischemia-reperfusion injury is not exclusively dependent on indolamine 2,3-dioxygenase inhibition. Biomed Pharmacother. 2021 Mar;135:111180. |[5]Jiang X, et al. Role of the indoleamine-2,3-dioxygenase/kynurenine pathway of tryptophan metabolism in behavioral alterations in a hepatic encephalopathy rat model. J Neuroinflammation. 2018 Jan 4;15(1):3.|[6]Oh JE, et al. 1-Methyl-L-tryptophan promotes the apoptosis of hepatic stellate cells arrested by interferon-γ by increasing the expression of IFN-γRβ, IRF-1 and FAS. Int J Mol Med. 2017 Aug;40(2):576-582.
- Research Area:
- Cancer; Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
