Alizarin
Product Sizes
500 mg
£ POA
HY-N0563-500MG
5 g
£ POA
HY-N0563-5G
1 g
£ POA
HY-N0563-1G
10mM/1mL
£ POA
HY-N0563-10MM
About this Product
- SKU:
- HY-N0563
- CAS Number:
- 72-48-0
- Extra Details:
- Alizarin is a natural dye. Alizarin can be extracted from the roots of madder plant. Alizarin activates AMPK and VEGFR2/eNOS pathway. Alizarin regulates PI3K/Akt and inhibits NF-κB pathway. Alizarin enhances CYP1A1 enzyme activity. Alizarin has protective effects on hypertension and vascular endothelial dysfunction. Alizarin has anti-tumor activity against multiple cancers including pancreatic cancer; breast cancer; osteosarcoma and liver cancer. Alizarin has been widely used as a pigment in textile fabrics and paintings[1][2][3][4][5][6][7].
- Molecular Weight:
- 240.21
- Purity:
- 99.48
- References:
- [1]Jen M, et al. Ultrafast Intramolecular Proton Transfer of Alizarin Investigated by Femtosecond Stimulated Raman Spectroscopy. J Phys Chem B. 2017 Apr 27;121(16):4129-4136.|[2]Xu Z, et al. Alizarin, a nature compound, inhibits the growth of pancreatic cancer cells by abrogating NF-κB activation. Int J Biol Sci. 2022 Mar 28;18(7):2759-2774.|[3]Liang S, et al. Alizarin, an Agonist of AHR Receptor, Enhances CYP1A1 Enzyme Activity and Induces Transcriptional Changes in Hepatoma Cells. Molecules. 2023 Oct 31;28(21):7373.|[4]Fotia C, et al. The natural compound Alizarin as an osteotropic drug for the treatment of bone tumors. J Orthop Res. 2012 Sep;30(9):1486-92.|[5]Xu L, et al. Alizarin increase glucose uptake through PI3K/Akt signaling and improve alloxan-induced diabetic mice. Future Med Chem. 2019 Mar;11(5):395-406.|[6]Qian YW, et al. The antihypertensive effect of Alizarin is achieved by activating VEGFR2/eNOS pathway, attenuating oxidative stress-induced mitochondrial damage and premature senescence. Life Sci. 2024 Aug 15;351:122862.|[7]Zhu ML, et al. Protective effect of alizarin on vascular endothelial dysfunction via inhibiting the type 2 diabetes-induced synthesis of THBS1 and activating the AMPK signaling pathway. Phytomedicine. 2024 Jun;128:155557.
- Research Area:
- Cancer; Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores
- Pathway:
- Epigenetics;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR;Protein Tyrosine Kinase/RTK
