(Z)-Ligustilide
Product Sizes
5 mg
HY-N0401A-5MG
20 mg
HY-N0401A-20MG
10 mg
HY-N0401A-10MG
About this Product
- SKU:
- HY-N0401A
- CAS Number:
- 81944-09-4
- Extra Details:
- (Z)-Ligustilide is extracted from Ligusticum chuanxiong Hort; has antimicrobial and antifungal activity; exhibits an average antifungal score of 5.6[1]. (Z)-Ligustilide is orally active; it inhibits the expression of FATP5 and DGAT; inhibits fatty acid uptake and esterification in mice and has potential as therapeutics for nonalcoholic fatty liver disease (NAFLD) [2]. (Z)-Ligustilide is also able to reactivate ERα; has epigenetic regulation; and is used in the study of tamoxifen-resistant breast cancer[3].
- Molecular Weight:
- 190.24
- Purity:
- 99.17
- References:
- [1]Rodrigues AMS, et al. The antifungal potential of (Z)-ligustilide and the protective effect of eugenol demonstrated by a chemometric approach. Sci Rep. 2019 Jun 19;9(1):8729. doi: 10.1038/s41598-019-45222-y|[2]Ma H, et al. Z-ligustilide restores tamoxifen sensitivity of ERa negative breast cancer cells by reversing MTA1/IFI16/HDACs complex mediated epigenetic repression of ERa. Oncotarget. 2017 Apr 25;8(17):29328-29345.|[3]Lee W, et al. Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo. Planta Med. 2019 Jul;85(9-10):719-728.
- Research Area:
- Cancer;Infection;Metabolic Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; protect from light; stored under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection;Membrane Transporter/Ion Channel;Vitamin D Related/Nuclear Receptor
