(+)-Columbianetin
Product Sizes
5 mg
£ POA
HY-N0363-5MG
20 mg
£ POA
HY-N0363-20MG
10 mg
£ POA
HY-N0363-10MG
10mM/1mL
£ POA
HY-N0363-10MM
About this Product
- SKU:
- HY-N0363
- Additional Names:
- (S)-Columbianetin
- CAS Number:
- 3804-70-4
- Extra Details:
- (+)-Columbianetin acts as an inhibitor of JNK and ERK as well as an activator of TGFβ signaling. (+)-Columbianetin inhibits UVA-induced phosphorylation of JNK and ERK; reduces the production of MMP-1; reverses UVA-induced collagen degradation; and alleviates UVA-mediated inhibition of Smad2/3 phosphorylation and translocation. (+)-Columbianetin regulates the AP-1 and ASK1-MAPK signaling pathways; inhibits the production of ROS; blocks sub-G1 cell cycle arrest; modulates the expression of MMP; and protects human keratinocytes against UVB-induced damage. (+)-Columbianetin is applicable to research related to skin aging[1][2].
- Molecular Weight:
- 246.26
- Purity:
- 99.04
- References:
- [1]UziAfek, et al. Columbianetin, a phytoalexin associated with celery resistance to pathogens during storage. 1995. Volume 39, Issue 6, August 1995, Pages 1347-1350.|[2]Jeong HJ, et al. Anti-inflammatory effect of Columbianetin on activated human mast cells. Biol Pharm Bull. 2009 Jun;32(6):1027-31.
- Research Area:
- Others
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection
