(+)-Magnoflorine
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HY-N0334-1EACH
About this Product
- SKU:
- HY-N0334
- Additional Names:
- Magnoflorine; α-Magnoflorine; Thalictrine
- Application:
- Electron Microscopy
- CAS Number:
- 2141-09-5
- Extra Details:
- (+)-Magnoflorine (α-Magnoflorine) is an orally active aporphine alkaloid with multiple biological activities. (+)-Magnoflorine promotes Parkin/PINK1 -mediated mitochondrial autophagy; inhibits the activation of NLRP3/Caspase-1 pathway; regulates the intestinal microbiota; and exhibits significant anti-inflammatory and immunomodulatory activities. (+)-Magnoflorine inhibits JNK and TLR4/NF-κB signaling pathways; activates Sirt1/AMPK pathway; alleviates neuronal oxidative stress and apoptosis. Magnoflorine upregulates miR-410-3p; inhibits HMGB1/NF-κB pathway; and has anti-tumor activity. (+)-Magnoflorine also has significant antifungal activity[1][2][3][4][5][6][7].
- Molecular Weight:
- 342.41
- References:
- [1]Kim J, et al. Antifungal activity of magnoflorine against Candida strains. World J Microbiol Biotechnol. 2018 Oct 31;34(11):167.|[2]Haque MA, et al. Magnoflorine Enhances LPS-Activated Pro-Inflammatory Responses via MyD88-Dependent Pathways in U937 Macrophages. Planta Med. 2018 Nov;84(17):1255-1264.
- Research Area:
- Cancer;Cardiovascular Disease;Infection;Inflammation/Immunology;Metabolic Disease;Neurological Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
