IR-1048
Product Sizes
5 mg
£ POA
HY-D1450-5MG
25 mg
£ POA
HY-D1450-25MG
50 mg
£ POA
HY-D1450-50MG
10 mg
£ POA
HY-D1450-10MG
About this Product
- SKU:
- HY-D1450
- Additional Names:
- S01448
- CAS Number:
- 155613-98-2
- Extra Details:
- IR-1048 is a nitroreductase (NTR)-responsive near-infrared fluorescence (NIR)/photoacoustic (PA) imaging probe and photothermal agent. IR-1048 is coupled with a nitroimidazole group to form IR-1048-MZ. IR-1048-MZ is catalytically reduced by NTR in a hypoxic environment; restoring strong near-infrared absorption and fluorescence emission (NIR II window); while activating the photothermal effect. IR-1048 relies on NTR-mediated electron transfer to relieve intramolecular fluorescence quenching; achieving specific imaging and photothermal ablation of tumor hypoxic areas. IR-1048 is mainly used for high-contrast NIR II/photoacoustic imaging and photothermal therapy research and tumor diagnosis of the tumor hypoxic microenvironment[1][2].
- Molecular Weight:
- 739.91
- Purity:
- 97.0
- References:
- [1]Xiaoqing Meng, et al. Hypoxia-triggered single molecule probe for high-contrast NIR II/PA tumor imaging and robust photothermal therapy. Theranostics. 2018 Nov 15;8(21):6025-6034.|[2]Xiaoxu Kang, et al. Dual-Cascade Responsive Nanoparticles Enhance Pancreatic Cancer Therapy by Eliminating Tumor-Resident Intracellular Bacteria. Adv Mater. 2022 Dec;34(49):e2206765.
- Research Area:
- Cancer
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores
- Pathway:
- Others
