5(6)-Carboxy-2';7'-dichlorofluorescein diacetate
Product Sizes
5 mg
£ POA
HY-D1078-5MG
10 mg
£ POA
HY-D1078-10MG
10mM/1mL
£ POA
HY-D1078-10MM
About this Product
- SKU:
- HY-D1078
- CAS Number:
- 127770-45-0
- Extra Details:
- 5 (6)-Carboxy-2';7'-dichlorofluorescein diacetate is a fluorescein-based reactive oxygen species (ROS) probe and also a MRP2 substrate. 5 (6)-Carboxy-2';7'-dichlorofluorescein diacetate serves as a substrate for intracellular esterases; which cleave its acetate groups to generate a fluorescent product capable of detecting intracellular ROS. 5 (6)-Carboxy-2';7'-dichlorofluorescein diacetate is ATP-dependent and is transported via a single MRP2 binding site; it competes with LTC4 for MRP2 binding sites and inhibits MRP2-mediated LTC4 transport (Ex/Em = 496/525 nm)[1][2][3][4].
- Molecular Weight:
- 529.28
- Purity:
- 97.5
- References:
- [1]Pogue AI, et al. Metal-sulfate induced generation of ROS in human brain cells: detection using an isomeric mixture of 5- and 6-carboxy-2',7'-dichlorofluorescein diacetate (carboxy-DCFDA) as a cell permeant tracer. Int J Mol Sci. 2012;13(8):9615-26.
- Research Area:
- Others
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores
- Pathway:
- Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB
