7ACC2
Product Sizes
5 mg
£ POA
HY-D0713-5MG
2 mg
£ POA
HY-D0713-2MG
100 mg
£ POA
HY-D0713-100MG
10 mg
£ POA
HY-D0713-10MG
50 mg
£ POA
HY-D0713-50MG
25 mg
£ POA
HY-D0713-25MG
10mM/1mL
£ POA
HY-D0713-10MM
About this Product
- SKU:
- HY-D0713
- Application:
- Antibody Microarray
- CAS Number:
- 1472624-85-3
- Extra Details:
- 7ACC2 is a potent monocarboxylate transporter (MCT) inhibitor with an IC50 of 11 nM for inhibition of [14C]-lactate influx. 7ACC2 is also a potent inhibitor of mitochondrial pyruvate transport. 7ACC2 is an anticancer agent through inhibition of lactate flux[1][2].
- Molecular Weight:
- 309.32
- Purity:
- 99.95
- References:
- [1]Draoui N, et al. Synthesis and pharmacological evaluation of carboxycoumarins as a new antitumor treatment targeting lactate transport in cancer cells. Bioorg Med Chem. 2013 Nov 15;21(22):7107-17.|[2]Cyril Corbet, et al. Interruption of lactate uptake by inhibiting mitochondrial pyruvate transport unravels direct antitumor and radiosensitizing effects. Nat Commun. 2018 Mar 23;9(1):1208.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores
- Pathway:
- Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease
