7ACC1
Product Sizes
250 mg
£ POA
HY-D0067-250MG
1 g
£ POA
HY-D0067-1G
10mM/1mL
£ POA
HY-D0067-10MM
About this Product
- SKU:
- HY-D0067
- Additional Names:
- DEAC; Coumarin D 1421; D 1421
- Application:
- Antibody Microarray
- CAS Number:
- 50995-74-9
- Extra Details:
- 7ACC1 (DEAC; Coumarin D 1421; D 1421) is a monocarboxylate transporter 1 (MCT-1)/MCT-4 specifc blocker. 7ACC1 attenuates renal cancer cell proliferation; migration; invasion and down-regulates the levels of MCT1/MCT4 expression and extracellular lactate. 7ACC1 is promising for research of cancers[1][2][3].
- Molecular Weight:
- 261.28
- Purity:
- 99.97
- References:
- [1]Draoui N, et al. Antitumor activity of 7-aminocarboxycoumarin derivatives, a new class of potent inhibitors of lactate influx but not efflux. Mol Cancer Ther. 2014 Jun;13(6):1410-8.|[2]Guo C, et al. Monocarboxylate transporter 1 and monocarboxylate transporter 4 in cancer-endothelial co-culturing microenvironments promote proliferation, migration, and invasion of renal cancer cells. Cancer Cell Int. 2019 Jun 28;19:170. |[3]Mohamed F A, et al. Mitochondrial Pyruvate Carrier Inhibition Mitigates Murine Chronic Graft Versus Host Disease By Attenuating the Germinal Center Reaction[J]. Blood, 2023, 142: 459.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores
- Pathway:
- Membrane Transporter/Ion Channel
