Melperone
Product Sizes
100 mg
£ POA
HY-B2169-100MG
50 mg
£ POA
HY-B2169-50MG
5 mg
£ POA
HY-B2169-5MG
10 mg
£ POA
HY-B2169-10MG
10mM/1mL
£ POA
HY-B2169-10MM
About this Product
- SKU:
- HY-B2169
- CAS Number:
- 3575-80-2
- Extra Details:
- Melperone is a butyrophenone with atypical antipsychotic properties. Melperone is a multireceptor antagonist with Kds of 102 nM; 180 nM; 180 nM; and 150 nM for 5-HT2A; dopamine D2; α1-adrenergic; and α2-adrenergic receptors; respectively. Melperone has weak binding to histamine H1; 5-HT2C; 5-HT1A; 5-HT1D; and muscarinic receptors; with Kd values of 580 nM; 2100 nM; 2200 nM; 3400 nM; >10000 nM; respectively. Melperone is also a CYP2D6 inhibitor. Melperone can be used for the study of schizophrenia; and agitation in the elderly[1][2][3][4].
- Molecular Weight:
- 263.35
- Purity:
- 99.84
- References:
- [1]Hefner G, et al. Melperone but not bisoprolol or metoprolol is a clinically relevant inhibitor of CYP2D6: evidence from a therapeutic drug monitoring survey. J Neural Transm (Vienna). 2015 Nov;122(11):1609-17.|[2]Bobo WV, et al. Melperone, an aytpical antipsychotic drug with clozapine-like effect on plasma prolactin: contrast with typical neuroleptics. Hum Psychopharmacol. 2009 Jul;24(5):415-22.|[3]Ichikawa J, et al. The effect of chronic atypical antipsychotic drugs and haloperidol on amphetamine-induced dopamine release in vivo. Brain Res. 1992 Mar 6;574(1-2):98-104. |[4]Richelson E, et al. Binding of antipsychotic drugs to human brain receptors focus on newer generation compounds. Life Sci. 2000 Nov 24;68(1):29-39.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
