Licofelone
Product Sizes
50 mg
£ POA
HY-B1452-50MG
10 mg
£ POA
HY-B1452-10MG
5 mg
£ POA
HY-B1452-5MG
25 mg
£ POA
HY-B1452-25MG
10mM/1mL
£ POA
HY-B1452-10MM
About this Product
- SKU:
- HY-B1452
- Additional Names:
- ML-3000
- Application:
- Antibody Microarray
- CAS Number:
- 156897-06-2
- Extra Details:
- Licofelone (ML-3000) is a dual COX/5-lipoxygenase (5-LOX) inhibitor (IC50=0.21/0.18 μM; respectively) for the treatment of osteoarthritis. Licofelone exerts anti-inflammatory and anti-proliferative effects. Licofelone induces apoptosis; and decreases the production of proinflammatory leukotrienes and prostaglandins[1][2][3].
- Molecular Weight:
- 379.88
- Purity:
- 99.84
- References:
- [1]Tavolari S, et al. Licofelone, a dual COX/5-LOX inhibitor, induces apoptosis in HCA-7 colon cancer cells through the mitochondrial pathway independently from its ability to affect the arachidonic acid cascade. Carcinogenesis. 2008 Feb;29(2):371-80.|[2]Alvaro-Gracia JM, et al. Licofelone--clinical update on a novel LOX/COX inhibitor for the treatment of osteoarthritis. Rheumatology (Oxford). 2004 Feb;43 Suppl 1:i21-5.|[3]Laufer SA, et al. (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. J Med Chem. 1994 Jun 10;37(12):1894-7.
- Research Area:
- Cancer; Inflammation/Immunology
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease
