Terfenadine
Product Sizes
100 mg
£ POA
HY-B1193-100MG
10mM/1mL
£ POA
HY-B1193-10MM
About this Product
- SKU:
- HY-B1193
- Additional Names:
- (±)-Terfenadine; MDL-991
- Application:
- Antibody Microarray
- CAS Number:
- 50679-08-8
- Extra Details:
- Terfenadine ((±)-Terfenadine) is a potent open-channel blocker of hERG with an IC50 of 204 nM[1]. Terfenadine; an H1 histamine receptor antagonist; acts as a potent apoptosis inducer in melanoma cells through modulation of Ca2+ homeostasis. Terfenadine induces ROS-dependent apoptosis; simultaneously activates Caspase-4; -2; -9[2].
- Molecular Weight:
- 471.67
- Purity:
- 99.98
- References:
- [1]Kamiya K, et al. Molecular determinants of hERG channel block by terfenadine and cisapride. J Pharmacol Sci. 2008 Nov;108(3):301-307.|[2]Nicolau-Galmés F, et al. Terfenadine induces apoptosis and autophagy in melanoma cells through ROS-dependent and -independent mechanisms. Apoptosis. 2011 Dec;16(12):1253-67.|[3]An L, et al. Terfenadine combined with epirubicin impedes the chemo-resistant human non-small cell lung cancer both in vitro and in vivo through EMT and Notch reversal. Pharmacol Res. 2017 Oct;124:105-115.
- Research Area:
- Cancer; Inflammation/Immunology; Endocrinology
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;GPCR/G Protein;Immunology/Inflammation;Membrane Transporter/Ion Channel;Neuronal Signaling
