Dibenzothiophene
Product Sizes
1 g
£ POA
HY-B0973-1G
500 mg
£ POA
HY-B0973-500MG
25 g
£ POA
HY-B0973-25G
5 g
£ POA
HY-B0973-5G
10mM/1mL
£ POA
HY-B0973-10MM
About this Product
- SKU:
- HY-B0973
- Additional Names:
- DBT; Diphenylene sulfide
- CAS Number:
- 132-65-0
- Extra Details:
- Dibenzothiophene is an orally active and a noncompetitive CYP1A inhibitor. Dibenzothiophene inhibits CYP1A-mediated EROD activity with a Km of 0.592 μM. Dibenzothiophene interacts with the AHR pathway. Dibenzothiophene enhances the embryotoxicity of β-naphthoflavone (HY-114740). Dibenzothiophene shows acute toxicity in mice. Dibenzothiophene is mainly used for the study of the mechanism of developmental toxicity in organisms[1][2].
- Molecular Weight:
- 184.26
- Purity:
- 99.98
- References:
- [1]Wassenberg DM, et al. Effects of the polycyclic aromatic hydrocarbon heterocycles, carbazole and dibenzothiophene, on in vivo and in vitro CYP1A activity and polycyclic aromatic hydrocarbon-derived embryonic deformities. Environ Toxicol Chem. 2005 Oct;24(10):2526-32. |[2]Leighton FA. Acute oral toxicity of dibenzothiophene for male CD-1 mice: LD50, lesions, and the effect of preinduction of mixed-function oxidases. Fundam Appl Toxicol. 1989 May;12(4):787-92.
- Research Area:
- Metabolic Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Immunology/Inflammation;Metabolic Enzyme/Protease
