3;6-Diaminoacridine (hemisulfate)
Product Sizes
100 mg
£ POA
HY-B0883-100MG
10mM/1mL
£ POA
HY-B0883-10MM
About this Product
- SKU:
- HY-B0883
- Additional Names:
- Proflavin hemisulfate; 3,6-Diaminoacridine hemisulfate
- CAS Number:
- 1811-28-5
- Extra Details:
- Proflavine hemisulfate is a multifunctional acridine compound. 3;6-Diaminoacridine hemisulfate is an acridine dye and also a DNA inserter. Proflavine hemisulfate is a potent broad-spectrum antibacterial agent; and its mechanism is to insert into bacterial DNA; interfering with replication and transcription; causing bacterial lysis. 3;6-Diaminoacridine hemisulfate is a Kir3.2 potassium channel blocker and can be used to study the neurological phenotype of Down syndrome. 3;6-Diaminoacridine hemisulfate can penetrate the stratum corneum of the skin and accumulate in the cell nucleus and long-term exposure may induce skin cancer or other malignant tumors[1][2][3].
- Molecular Weight:
- 258.28
- Purity:
- 98.78
- References:
- [1]Hitoshi Kawada, et al. Isolation of proflavine as a blocker of G protein-gated inward rectifier potassium channels by a cell growth-based screening system. Neuropharmacology. 2016 Oct;109:18-28.|[2]Mansour K.Gatasheh, et al. Proflavine an acridine DNA intercalating agent and strong antimicrobial possessing potential properties of carcinogen. Karbala International Journal of Modern Science. 2017 Dec, 3(4): 272-278.|[3]Jiaxin Chen, et al. Determination of proflavine in rat whole blood without sample pretreatment by laser desorption postionization mass spectrometry. Anal Bioanal Chem. 2017 Apr;409(11):2813-2819.
- Research Area:
- Cancer;Infection;Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture and light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Fluorophores
- Pathway:
- Anti-infection;Autophagy;Membrane Transporter/Ion Channel
