Ospemifene
Product Sizes
200 mg
£ POA
HY-B0723-200MG
50 mg
£ POA
HY-B0723-50MG
100 mg
£ POA
HY-B0723-100MG
5 mg
£ POA
HY-B0723-5MG
10 mg
£ POA
HY-B0723-10MG
10mM/1mL
£ POA
HY-B0723-10MM
25 mg
£ POA
HY-B0723-25MG
About this Product
- SKU:
- HY-B0723
- Additional Names:
- FC-1271a
- Application:
- Antibody Microarray
- CAS Number:
- 128607-22-7
- Extra Details:
- Ospemifene (FC-1271a) is an orally active and non-estrogenic selective estrogen receptor modulator (SERM) with Ki values of 380 and 410 nM for estrogen receptor α (ERα) and ERβ; respectively. Ospemifene inhibits caspase-3 activity. Ospemifene inhibits neuronal degeneration; prevents bone loss; and increases vaginal weight and vaginal epithelial height. Ospemifene has anticancer activity against breast cancer[1][2][3][4][5][6].
- Molecular Weight:
- 378.89
- Purity:
- 99.84
- References:
- [1]Qiang Qv.et al.Selective estrogenic effects of a novel triphenylethylene compound, FC1271a, on bone, cholesterol level, and reproductive tissues in intact and ovariectomized rats. Endocrinology.Feb;141(2):809-20. 25. (2000).|[2]Tracy L. Taras et al.In vitro and in vivo biologic effects of Ospemifene (FC-1271a) in breast cancer. The Journal of Steroid Biochemistry and Molecular Biology 77(4-5):271-9,(2001).|[3]Unkila M, et, al. Vaginal effects of ospemifene in the ovariectomized rat preclinical model of menopause. J Steroid Biochem Mol Biol. 2013 Nov;138:107-15.|[4]Bruyniks N, et, al. Systematic indirect comparison of ospemifene versus local estrogens for vulvar and vaginal atrophy. Climacteric. 2017 Jun; 20(3): 195-204.|[5]Pietrzak B A, et al. Posttreatment with ospemifene attenuates hypoxia-and ischemia-induced apoptosis in primary neuronal cells via selective modulation of estrogen receptors. Neurotoxicity Research, 2023, 41(4): 362-379.|[6]Burich RA, et al. Ospemifene and 4-hydroxyospemifene effectively prevent and treat breast cancer in the MTag.Tg transgenic mouse model. Menopause. 2012 Jan;19(1):96-103.
- Research Area:
- Cancer; Endocrinology; Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Vitamin D Related/Nuclear Receptor
