Tafluprost acid
Product Sizes
5 mg
£ POA
HY-B0601-5MG
1 mg
£ POA
HY-B0601-1MG
10 mg
£ POA
HY-B0601-10MG
About this Product
- SKU:
- HY-B0601
- Additional Names:
- AFP-172
- Application:
- Immunoprecipitation
- CAS Number:
- 209860-88-8
- Extra Details:
- Tafluprost acid (AFP-172); an active metabolic form of Tafluprost; is a selective prostanoid FP receptor agonist. Tafluprost acid shows a high affinity for human prostanoid FP receptor with Ki and EC50 values of 0.4 nM and 0.53 nM; respectively. Tafluprost acid has 126 times weaker binding affinity for prostanoid EP3 receptor (IC50=67 nM) than for the prostanoid FP receptor. Tafluprost acid can be used in the research of glaucoma[1][2][3].
- Molecular Weight:
- 410.45
- Purity:
- 99.80
- References:
- [1]Takagi Y, et al. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp Eye Res. 2004 Apr;78(4):767-76.|[2]Taketani Y, et al. Activation of the prostanoid FP receptor inhibits adipogenesis leading to deepening of the upper eyelid sulcus in prostaglandin-associated periorbitopathy. Invest Ophthalmol Vis Sci. 2014 Mar 4;55(3):1269-76.|[3]Roh YJ, et al. Effects of AFP-172 on COX-2-induced angiogenic activities on human umbilical vein endothelial cells. Graefes Arch Clin Exp Ophthalmol. 2012 Dec;250(12):1765-75.|[4]Fuwa M, et al. Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination. PLoS One. 2016 Jul 6;11(7):e0158797.
- Research Area:
- Endocrinology; Neurological Disease; Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; protect from light)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Metabolic Enzyme/Protease
