Tolbutamide
Product Sizes
500 mg
£ POA
HY-B0401-500MG
1 g
£ POA
HY-B0401-1G
5 g
£ POA
HY-B0401-5G
10mM/1mL
£ POA
HY-B0401-10MM
About this Product
- SKU:
- HY-B0401
- CAS Number:
- 64-77-7
- Extra Details:
- Tolbutamide is an orally active KATP inhibitor. Tolbutamide inhibits cell proliferation; stimulates exocytosis of glucagon and reduces fetal lethality of mice. Tolbutamide can be used in the research of diabete[1][2][3][4].
- Molecular Weight:
- 270.35
- Purity:
- 99.96
- References:
- [1]Sánchez‐Alvarez R, et al. Tolbutamide reduces glioma cell proliferation by increasing connexin43, which promotes the up‐regulation of p21 and p27 and subsequent changes in retinoblastoma phosphorylation [J]. Glia, 2006, 54(2): 125-134.|[2]Hœy M, et al. Tolbutamide stimulates exocytosis of glucagon by inhibition of a mitochondrial‐like ATP‐sensitive K+ (KATP) conductance in rat pancreatic A‐cells [J]. The Journal of Physiology, 2000, 527(1): 109-120.|[3]Williams A J K, et al. Tolbutamide reduces the incidence of diabetes mellitus, but not insulitis, in the non-obese-diabetic mouse [J]. Diabetologia, 1993, 36: 487-492.|[4]Belisle R J, et al. Tolbutamide treatment of pregnant mice: repeated administration reduces fetal lethality [J]. Teratology, 1976, 13(1): 65-70.
- Research Area:
- Metabolic Disease; Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel
