(S)-(+)-Rolipram
Product Sizes
10 mg
£ POA
HY-B0392-10MG
50 mg
£ POA
HY-B0392-50MG
5 mg
£ POA
HY-B0392-5MG
100 mg
£ POA
HY-B0392-100MG
10mM/1mL
£ POA
HY-B0392-10MM
About this Product
- SKU:
- HY-B0392
- Additional Names:
- (+)-Rolipram; (S)-Rolipram
- CAS Number:
- 85416-73-5
- Extra Details:
- (S)-(+)-Rolipram ((+)-Rolipram) is a cyclic AMP(cAMP)-specific phosphodiesterase 4 (PDE4) inhibitor; with an IC50 of 1100 nM. (S)-(+)-Rolipram can suppresse tumor necrosis factor-alpha (TNFα) production by human mononuclear cells[1][2][3].
- Molecular Weight:
- 275.35
- Purity:
- 99.96
- References:
- [1]Semmler J, et, al. The specific type IV phosphodiesterase inhibitor rolipram suppresses tumor necrosis factor-alpha production by human mononuclear cells. Int J Immunopharmacol. 1993 Apr;15(3):409-13.|[2]Wachtel H. Neurotropic effects of the optical isomers of the selective adenosine cyclic 3',5'-monophosphate phosphodiesterase inhibitor rolipram in rats in-vivo. J Pharm Pharmacol. 1983 Jul;35(7):440-4.|[3]Ortmann R, et, al. Rolipram forms a potent discriminative stimulus in drug discrimination experiments in rats. Psychopharmacology (Berl). 1986;89(3):273-7.
- Research Area:
- Cancer; Inflammation/Immunology; Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Metabolic Enzyme/Protease
