Clemastine (fumarate)
Product Sizes
500 mg
£ POA
HY-B0298A-500MG
100 mg
£ POA
HY-B0298A-100MG
200 mg
£ POA
HY-B0298A-200MG
10mM/1mL
£ POA
HY-B0298A-10MM
About this Product
- SKU:
- HY-B0298A
- Additional Names:
- HS-592 (fumarate); Meclastine (fumarate)
- CAS Number:
- 14976-57-9
- Extra Details:
- Clemastine (HS-592; Meclastine) fumarate is an orally active; blood-brain barrier-permeable H1 histamine receptor (H1 histamine receptor) antagonist with potent antiallergic effects. Clemastine fumarate also antagonizes muscarinic acetylcholine receptors (mAChR); particularly the M1 and M4 subtypes. In addition to antihistamine effects; Clemastine fumarate exhibits multiple pharmacological activities; especially in promoting central nervous system remyelination; activating autophagy and pyroptosis; exerting anti-apoptotic and neuroprotective effects; and suppressing inflammation [1][2][3][4][5][6].
- Molecular Weight:
- 459.96
- Purity:
- 99.96
- References:
- [1]Seifert, R., et al., Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol, 1992. 42(2): p. 227-34.|[2]Clemastine. In: LiverTox: Clinical and Research Information on Drug-Induced Liver Injury. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; January 16, 2017.
- Research Area:
- Metabolic Disease;Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
