Aminoglutethimide
Product Sizes
500 mg
£ POA
HY-B0237-500MG
100 mg
£ POA
HY-B0237-100MG
10mM/1mL
£ POA
HY-B0237-10MM
About this Product
- SKU:
- HY-B0237
- Additional Names:
- DL-Aminoglutethimide
- CAS Number:
- 125-84-8
- Extra Details:
- Aminoglutethimide (DL-Aminoglutethimide) is an orally active anticonvulsant with various endocrine-related side effects. Aminoglutethimide blocks multiple steroid hormone synthesis pathways by inhibiting several cytochrome P-450-dependent hydroxylases; such as aromatase; cholesterol side-chain cleavage enzyme; 11-hydroxylase; and 18-hydroxylase; with IC50 values of 0.3; 3.5; 120; and 20 μM; respectively. Aminoglutethimide reduces cortisol levels. Aminoglutethimide can be used in research on Cushing's syndrome; breast cancer; and other conditions[1][2][3][4].
- Molecular Weight:
- 232.28
- Purity:
- 98.79
- References:
- [1]Fassnacht, M., et al., Aminoglutethimide suppresses adrenocorticotropin receptor expression in the NCI-h295 adrenocortical tumor cell line. J Endocrinol, 1998. 159(1): p. 35-42.|[2]Neves, M.A., et al., An efficient steroid pharmacophore-based strategy to identify new aromatase inhibitors. Eur J Med Chem, 2009. 44(10): p. 4121-7.|[3]Bastida, C.M., et al., Aminoglutethimide, a steroidogenesis inhibitor, abolishes hormonal induction of ornithine decarboxylase in steroidogenic tissues: evidence for its role as cAMP-dependent protein kinase inhibitor. Biochem Biophys Res Commun, 2001. 281(1): p. 244-8.
- Research Area:
- Cancer;Endocrinology;Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
