Prazosin (hydrochloride)
Product Sizes
200 mg
£ POA
HY-B0193A-200MG
100 mg
£ POA
HY-B0193A-100MG
500 mg
£ POA
HY-B0193A-500MG
10mM/1mL
£ POA
HY-B0193A-10MM
About this Product
- SKU:
- HY-B0193A
- CAS Number:
- 19237-84-4
- Extra Details:
- Prazosin hydrochloride is a well-tolerated; CNS-active α1-adrenergic receptor antagonist for the research of high blood pressure and alcohol use disorders[1]. Prazosin hydrochloride potently inhibits Norepinephrine (NE)-stimulated 45Ca efflux with an IC50 of 0.15 nM[2].Prazosin hydrochloride inhibits organic cation transporters OCT-1 and OCT-3 with IC50s of 1.8; and 13 μM; respectively[3].
- Molecular Weight:
- 419.86
- Purity:
- 99.93
- References:
- [1]Dennis D Rasmussen, et al. The alpha1-adrenergic receptor antagonist, prazosin, reduces alcohol drinking in alcohol-preferring (P) rats. Alcohol Clin Exp Res. 2009 Feb;33(2):264-72.|[2]W S Colucci, et al. Nonlinear relationship between alpha 1-adrenergic receptor occupancy and norepinephrine-stimulated calcium flux in cultured vascular smooth muscle cells.Mol Pharmacol. 1985 May;27(5):517-24.|[3]Deborah L White, et al. OCT-1-mediated influx is a key determinant of the intracellular uptake of imatinib but not nilotinib (AMN107): reduced OCT-1 activity is the cause of low in vitro sensitivity to imatinib.Blood. 2006 Jul 15;108(2):697-704.|[4]Jing Zhang, et al. Prazosin inhibits the proliferation, migration and invasion, but promotes the apoptosis of U251 and U87 cells via the PI3K/AKT/mTOR signaling pathway. Exp Ther Med. 2020 Aug;20(2):1145-1152.
- Research Area:
- Cardiovascular Disease; Endocrinology; Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Autophagy;GPCR/G Protein;Neuronal Signaling
