Pregnenolone
Product Sizes
500 mg
£ POA
HY-B0151-500MG
5 g
£ POA
HY-B0151-5G
1 g
£ POA
HY-B0151-1G
10 g
£ POA
HY-B0151-10G
25 g
£ POA
HY-B0151-25G
10mM/1mL
£ POA
HY-B0151-10MM
About this Product
- SKU:
- HY-B0151
- Additional Names:
- 3β-Hydroxy-5-pregnen-20-one
- CAS Number:
- 145-13-1
- Extra Details:
- Pregnenolone (3β-Hydroxy-5-pregnen-20-one) is a powerful neurosteroid; the main precursor of various steroid hormones including steroid ketones. Pregnenolone acts as a signaling-specific inhibitor of cannabinoid CB1 receptor; inhibits the effects of tetrahydrocannabinol (THC) that are mediated by the CB1 receptors. Pregnenolone can protect the brain from cannabis intoxication[1][2]. Pregnenolone is also a TRPM3 channel activator; and also can weakly activate TRPM1 channels[3].
- Molecular Weight:
- 316.48
- Purity:
- 99.85
- References:
- [1]Vallée M, et al. Pregnenolone can protect the brain from cannabis intoxication. Science. 2014 Jan 3;343(6166):94-8.|[2]Ducharme N, et al. Brain distribution and behavioral effects of progesterone and pregnenolone after intranasal or intravenous administration. Eur J Pharmacol. 2010 Sep 1;641(2-3):128-34.|[3]Alan Shiels. TRPM3_miR-204: a complex locus for eye development and disease. Hum Genomics. 2020 Feb 18;14(1):7.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Autophagy;GPCR/G Protein;Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
