Zonisamide
Product Sizes
200 mg
£ POA
HY-B0124-200MG
500 mg
£ POA
HY-B0124-500MG
10mM/1mL
£ POA
HY-B0124-10MM
About this Product
- SKU:
- HY-B0124
- Additional Names:
- AD 810; CI 912
- CAS Number:
- 68291-97-4
- Extra Details:
- Zonisamide (AD 810) is an orally active carbonic anhydrase inhibitor; with Kis of 35.2 and 20.6 nM for hCA II and hCA V; respectively. Zonisamide exerts neuroprotective effects through anti-apoptosis and upregulating MnSOD levels. Zonisamide also increases the expression of Hrd1; thereby improving cardiac function in AAC rats. Zonisamide can be used in studies of seizure; parkinson’s disease and cardiac hypertrophy[1][2][3][4].
- Molecular Weight:
- 212.23
- Purity:
- 99.95
- References:
- [1]Kawajiri S, et al. Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD. Neurosci Lett. 2010 Sep 6;481(2):88-91. |[2]Ueda Y, et al. Effect of zonisamide on molecular regulation of glutamate and GABA transporter proteins during epileptogenesis in rats with hippocampal seizures. Brain Res Mol Brain Res. 2003 Aug 19;116(1-2):1-6. |[3]Wu Q, et al. Zonisamide alleviates cardiac hypertrophy in rats by increasing Hrd1 expression and inhibiting endoplasmic reticulum stress. Acta Pharmacol Sin. 2021 Oct;42(10):1587-1597.|[4]De Simone G, et al. Carbonic anhydrase inhibitors. Zonisamide is an effective inhibitor of the cytosolic isozyme II and mitochondrial isozyme V: solution and X-ray crystallographic studies. Bioorg Med Chem Lett. 2005 May 2;15(9):2315-20.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Apoptosis;Metabolic Enzyme/Protease
