Topiramate
Product Sizes
100 mg
£ POA
HY-B0122-100MG
500 mg
£ POA
HY-B0122-500MG
10mM/1mL
£ POA
HY-B0122-10MM
About this Product
- SKU:
- HY-B0122
- Additional Names:
- McN 4853; RWJ 17021
- CAS Number:
- 97240-79-4
- Extra Details:
- Topiramate (McN 4853) is a broad-spectrum antiepileptic agent. Topiramate is a GluR5 receptor antagonist. Topiramate produces its antiepileptic effects through enhancement of GABAergic activity; inhibition of kainate/AMPA receptors; inhibition of voltage-sensitive sodium and calcium channels; increases in potassium conductance; and inhibition of carbonic anhydrase[1][2][3].
- Molecular Weight:
- 339.36
- Purity:
- 99.76
- References:
- [1]Lyseng-Williamson KA, et al. Topiramate: a review of its use in the treatment of epilepsy. Drugs. 2007;67(15):2231-56.|[2]Nakamura J, et al. Target pharmacology of topiramate, a new antiepileptic drug. Nihon Yakurigaku Zasshi. 2000 Jan;115(1):53-7.|[3]Kaminski RM, et al. Topiramate selectively protects against seizures induced by ATPA, a GluR5 kainate receptor agonist. Neuropharmacology. 2004 Jun;46(8):1097-104.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
