Pamidronic acid (sodium)
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HY-B0012B-1EACH
About this Product
- SKU:
- HY-B0012B
- CAS Number:
- 89131-02-2
- Extra Details:
- Pamidronic acid sodium; the second-generation nitrogen-containing bisphosphonate; is an inhibitor of bone loss. Pamidronic acid sodium significantly inhibits subchondral bone loss in early osteoarthritis by upregulating the expression of osteoprotegerin in cartilage and subchondral bone; and inhibiting the expression of RANKL and MMP-9 in both tissues; as well as TLR-4 in cartilage; thereby alleviating cartilage degeneration. Additionally; Pamidronic acid sodium can inhibit the signaling of Wnt and β-catenin; and is applicable for research on osteoporosis and osteosarcoma[1][2][3][4].
- Molecular Weight:
- 257.05
- References:
- [1]Kovacs R, et al. The synthesis of pamidronic derivatives in different solvents: An optimization and a mechanistic study[J]. Heteroatom Chemistry, 2014, 25(3): 186-193.|[2]Ashton JA, et al. Investigation of the effect of pamidronate disodium on the in vitro viability of osteosarcoma cellsfrom dogs. Am J Vet Res. 2005 May;66(5):885-91.|[3]Xu Y, et al. Pamidronate Disodium Leads to Bone Necrosis via Suppression of Wnt/β-Catenin Signaling in Human Bone Marrow Mesenchymal Stem Cells In Vitro. J Oral Maxillofac Surg. 2017 Mar 22.|[4]Lv Y, et al. Effects of pamidronate disodium on the loss of osteoarthritic subchondral bone and the expression of cartilaginous and subchondral osteoprotegerin and RANKL in rabbits. BMC Musculoskelet Disord. 2014 Nov 6;15:370.
- Research Area:
- Cancer; Metabolic Disease; Inflammation/Immunology
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
