Thiothixene
Product Sizes
1 mg
£ POA
HY-A0139-1MG
About this Product
- SKU:
- HY-A0139
- Additional Names:
- NSC 108165; Navan; Navane
- CAS Number:
- 5591-45-7
- Extra Details:
- Thiothixene is a typical antipsychotic. It selectively binds to dopamine D2 over D1; D3; and D4 receptors (Kis=0.417; 338; 186.2; and 363.1 nM; respectively). Thiothixene also binds to various serotonin (5-HT); histamine H1; α1- and α2-adrenergic; muscarinic acetylcholine; and sigma receptors (Kis=15-5;754 nM) as well as the dopamine; norepinephrine; and serotonin transporters (Kis=3.16-30 μM). In vivo; thiothixene reduces spontaneous and amphetamine-induced locomotor activity in rats. It enhances latent inhibition; as measured by a decreased lick latency in response to light and foot shock stimuli; which is a measure of selective attention in rats.3 Thiothixene also increases competitive behavior in submissive mice; indicating antidepressant-like behavior.
- Molecular Weight:
- 443.63
- References:
- [1]Silvestre, et al. Research on adverse drug events. I. Muscarinic M3 receptor binding affinity could predict the risk of antipsychotics to induce type 2 diabetes. Methods Find. Exp. Clin. Pharmacol. 27(5), 289-304 (2005).
- Research Area:
- Others
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Immunology/Inflammation;Neuronal Signaling
