(Rac)-5-Hydroxymethyl Tolterodine-d14
Product Sizes
10 mg
£ POA
HY-76570S-10MG
1 mg
£ POA
HY-76570S-1MG
About this Product
- SKU:
- HY-76570S
- Additional Names:
- (Rac)-Desfesoterodine-d14; (Rac)-PNU-200577-d14
- CAS Number:
- 1185071-13-9
- Extra Details:
- (Rac)-5-Hydroxymethyl Tolterodine-d14 is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine); an active metabolite of Tolterodine; is a mAChR antagonist (Ki values of 2.3 nM; 2 nM; 2.5 nM; 2.8 nM; and 2.9 nM for M1; M2; M3; M4; and M5 receptors; respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research[1].
- Molecular Weight:
- 355.57
- References:
- [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. |[2]L Nilvebrant, et al. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol. 1997 Oct;81(4):169-72.|[3]B Malhotra, et al. The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Curr Med Chem. 2009;16(33):4481-9.|[4]Shizuo Yamada, et al. Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration. J Pharmacol Sci. 2019 May;140(1):73-78.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
