(Rac)-5-Hydroxymethyl Tolterodine (hydrochloride)
Product Sizes
100 mg
£ POA
HY-76570A-100MG
1 g
£ POA
HY-76570A-1G
500 mg
£ POA
HY-76570A-500MG
About this Product
- SKU:
- HY-76570A
- Additional Names:
- (Rac)-Desfesoterodine (hydrochloride); (Rac)-PNU-200577 (hydrochloride);
- CAS Number:
- 250214-40-5
- Extra Details:
- (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine) hydrochloride; an active metabolite of Tolterodine; is a mAChR antagonist (Ki values of 2.3 nM; 2 nM; 2.5 nM; 2.8 nM; and 2.9 nM for M1; M2; M3; M4; and M5 receptors; respectively). (Rac)-5-Hydroxymethyl Tolterodine hydrochloride can be used for overactive bladder research[1].
- Molecular Weight:
- 377.95
- Purity:
- 97.84
- References:
- [1]L Nilvebrant, et al. Antimuscarinic potency and bladder selectivity of PNU-200577, a major metabolite of tolterodine. Pharmacol Toxicol. 1997 Oct;81(4):169-72.|[2]B Malhotra, et al. The design and development of fesoterodine as a prodrug of 5-hydroxymethyl tolterodine (5-HMT), the active metabolite of tolterodine. Curr Med Chem. 2009;16(33):4481-9.|[3]Shizuo Yamada, et al. Muscarinic receptor binding of fesoterodine, 5-hydroxymethyl tolterodine, and tolterodine in rat tissues after the oral, intravenous, or intravesical administration. J Pharmacol Sci. 2019 May;140(1):73-78.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; sealed storage; away from moisture)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Neuronal Signaling
