I2906
Product Sizes
500 mg
£ POA
HY-76293-500MG
100 mg
£ POA
HY-76293-100MG
50 mg
£ POA
HY-76293-50MG
25 mg
£ POA
HY-76293-25MG
10mM/1mL
£ POA
HY-76293-10MM
About this Product
- SKU:
- HY-76293
- CAS Number:
- 331963-29-2
- Extra Details:
- I2906 showed antimycobacterial and cytotoxic activity against mycobacterium tuberculosis. IC50 Value: Target: Antibacterial Under in vitro conditions; I2906 showed excellent antimycobacterial activities and low cytotoxicity. In a murine model infected with M. tuberculosis H37Rv; the reductions on bacterial loads of both lungs and spleen were statistically significant (p < 0.05) between I2906-treated mice and untreated controls after 4 weeks. Further; the colony-forming unit counts in the lungs were dramatically lower (p < 0.05) than that of isoniazid-treated mice by the addition of I2906 after 8 weeks. Moreover; survival rate was increased by I2906 treatment. For multidrug-resistant strain infection; bacterial counts were reduced significantly in the lungs and spleen due to I2906 treatment in comparison with data from untreated controls (p < 0.05).
- Molecular Weight:
- 443.58
- Purity:
- 99.83
- References:
- [1]Lu, Jingning; Yue, Jun; Wu, Jing et al. In vitro and in vivo Activities of a New Lead Compound I2906 against Mycobacterium tuberculosis. Pharmacology (2010), 85(6), 365-371.
- Research Area:
- Infection
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection
