(Rac)-LY341495
Product Sizes
5 mg
£ POA
HY-70059A-5MG
10 mg
£ POA
HY-70059A-10MG
50 mg
£ POA
HY-70059A-50MG
100 mg
£ POA
HY-70059A-100MG
25 mg
£ POA
HY-70059A-25MG
About this Product
- SKU:
- HY-70059A
- Extra Details:
- (Rac)-LY341495 is the isomers of LY341495 (HY-70059) can be used as control compounds in experiments. LY341495 is a metabotropic glutamate receptor (mGluR) antagonist with IC50s of 21 nM; 14 nM; 7.8 μM; 8.2 μM; 170 nM; 990 nM; 22 μM for mGlu2; mGlu3; mGlu1a; mGlu5a; mGlu8; mGlu7; and mGlu4 receptors; respectively[5].
- Molecular Weight:
- 353.37
- Purity:
- 96.52
- References:
- [1]A E Kingston, et al. LY341495 Is a Nanomolar Potent and Selective Antagonist of Group II Metabotropic Glutamate Receptors.Neuropharmacology. 1998;37(1):1-12.|[2]Pitsikas N, et al. The metabotropic glutamate 2/3 receptor antagonist LY341495 differentially affects recognition memory in rats. Behav Brain Res. 2012 May 1;230(2):374-9.|[3]Sutton LP, et al. Regulation of Akt and Wnt signaling by the group II metabotropic glutamate receptor antagonist LY341495 and agonist LY379268.J Neurochem. 2011 Jun;117(6):973-83.|[4]Linden AM, et al. Use of MGLUR2 and MGLUR3 knockout mice to explore in vivo receptor specificity of the MGLUR2/3 selective antagonist LY341495. Neuropharmacology. 2009 Aug;57(2):172-82. Epub 2009 May 27.|[5]Li J, et al. N-acetyl-cysteine attenuates neuropathic pain by suppressing matrix metalloproteinases. Pain. 2016 Aug;157(8):1711-23.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Neuronal Signaling
