1-Azakenpaullone
Product Sizes
25 mg
£ POA
HY-59090-25MG
10 mg
£ POA
HY-59090-10MG
50 mg
£ POA
HY-59090-50MG
5 mg
£ POA
HY-59090-5MG
100 mg
£ POA
HY-59090-100MG
2 mg
£ POA
HY-59090-2MG
10mM/1mL
£ POA
HY-59090-10MM
About this Product
- SKU:
- HY-59090
- Additional Names:
- 1-Akp
- Application:
- Immunoprecipitation
- CAS Number:
- 676596-65-9
- Extra Details:
- 1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β); with an IC50 value of 18 nM[1].
- Molecular Weight:
- 328.16
- Purity:
- 99.61
- References:
- [1]Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6.|[2]Li R, et al. Ionizing Radiation Blocks Hair Cell Regeneration in Zebrafish Lateral Line Neuromasts by Preventing Wnt Signaling. Mol Neurobiol. 2018 Feb;55(2):1639-1651.|[3]AlMuraikhi N, et al. Inhibition of GSK-3β Enhances Osteoblast Differentiation of Human Mesenchymal Stem Cells through Wnt Signalling Overexpressing Runx2. Int J Mol Sci. 2023 Apr 12;24(8):7164. |[4]Chan MH, et al. Inhibition of glycogen synthase kinase-3 attenuates psychotomimetic effects of ketamine. Schizophr Res. 2012 Apr;136(1-3):96-103.|[5]Shin S, et al. Glycogen synthase kinase-3β positively regulates protein synthesis and cell proliferation through the regulation of translation initiation factor 4E-binding protein 1. Oncogene. 2014 Mar 27;33(13):1690-9.
- Research Area:
- Metabolic Disease; Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- PI3K/Akt/mTOR;Stem Cell/Wnt
