Mavorixafor
Product Sizes
10 mg
£ POA
HY-50101-10MG
5 mg
£ POA
HY-50101-5MG
50 mg
£ POA
HY-50101-50MG
100 mg
£ POA
HY-50101-100MG
25 mg
£ POA
HY-50101-25MG
About this Product
- SKU:
- HY-50101
- Additional Names:
- AMD-070; AMD-11070
- CAS Number:
- 558447-26-0
- Extra Details:
- Mavorixafor (AMD-070) is a potent; selective and orally available CXCR4 antagonist; with an IC50 value of 13 nM against CXCR4 125I-SDF binding; and also inhibits the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs with an IC50 of 1 and 9 nM; respectively. Mavorixafor can be used for the study of WHIM syndrome[1].
- Molecular Weight:
- 349.47
- Purity:
- 99.72
- References:
- [1]Skerlj RT, et al. Discovery of novel small molecule orally bioavailable C-X-C chemokine receptor 4 antagonists that are potent inhibitors of T-tropic (X4) HIV-1 replication. J Med Chem. 2010 Apr 22;53(8):3376-88.|[2]Uchida D, et al. Effect of a novel orally bioavailable CXCR4 inhibitor, AMD070, on the metastasis of oral cancer cells. Oncol Rep. 2018 Jul;40(1):303-308.
- Research Area:
- Infection; Endocrinology; Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- 4[o]C (Powder; stored under nitrogen)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Anti-infection;GPCR/G Protein;Immunology/Inflammation
