Deschloroclozapine
Product Sizes
50 mg
£ POA
HY-42110-50MG
10 mg
£ POA
HY-42110-10MG
100 mg
£ POA
HY-42110-100MG
5 mg
£ POA
HY-42110-5MG
10mM/1mL
£ POA
HY-42110-10MM
1 g
£ POA
HY-42110-1G
25 mg
£ POA
HY-42110-25MG
About this Product
- SKU:
- HY-42110
- CAS Number:
- 1977-07-7
- Extra Details:
- Deschloroclozapine; a metabolite of Clozapine; is a highly potent muscarinic DREADDs agonist; with blood-brain barrier permeability. Deschloroclozapine binds to DREADD receptor subtypes hM3Dq and hM4Di with Ki of 6.3 and 4.2 nM; respectively. [11C]-Deschloroclozapine is developed as a promising PET tracer for DREADD imaging[1][2][3].
- Molecular Weight:
- 292.39
- Purity:
- 99.93
- References:
- [1]Maggs JL, et al. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man. J Pharmacol Exp Ther. 1995;275(3):1463-1475.|[2]Hu F, et al. <sup>18</sup>F-labeled radiotracers for in vivo imaging of DREADD with positron emission tomography. Eur J Med Chem. 2021;213:113047.|[3]Upright NA, et al. Effect of chemogenetic actuator drugs on prefrontal cortex-dependent working memory in nonhuman primates. Neuropsychopharmacology. 2020;45(11):1793-1798.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20[o]C; 3 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Neuronal Signaling
