1-Aminocyclopropane-1-carboxylic acid
Product Sizes
500 mg
£ POA
HY-30004-500MG
10 g
£ POA
HY-30004-10G
100 g
£ POA
HY-30004-100G
5 g
£ POA
HY-30004-5G
50 g
£ POA
HY-30004-50G
25 g
£ POA
HY-30004-25G
1 g
£ POA
HY-30004-1G
10mM/1mL
£ POA
HY-30004-10MM
About this Product
- SKU:
- HY-30004
- Application:
- Immunoprecipitation
- CAS Number:
- 22059-21-8
- Extra Details:
- 1-Aminocyclopropane-1-carboxylic acid is an endogenous metabolite. In the presence of low concentrations (1 μM) of glutamate; 1-Aminocyclopropane-1-carboxylic acid acts as a small molecule agonist of NMDA receptors with an EC50 of 0.7-0.9 μM. At high concentrations (10 μM) of glutamate; 1-Aminocyclopropane-1-carboxylic acid acts as a competitive antagonist of NMDA receptors with an EC50 of 81.6 nM. 1-Aminocyclopropane-1-carboxylic acid exerts neuroprotective activity by moderately activating NMDA receptors to prevent neuronal cell death in ischemic animal models. Additionally; 1-Aminocyclopropane-1-carboxylic acid is an antagonist of NMDA receptors; inducing blood pressure reduction and antioxidant effects in stroke-prone hypertensive rats. 1-Aminocyclopropane-1-carboxylic acid enhances object recognition memory and cognitive flexibility dependent on the prefrontal cortex; but does not affect impulsivity nor exhibit an antipsychotic-like profile. 1-Aminocyclopropane-1-carboxylic acid shows promise for research in the field of neurotoxicity.[1][2][3].
- Molecular Weight:
- 101.10
- Purity:
- 99.76
- References:
- [1]Nahum-Levy R,et al. Putative partial agonist 1-aminocyclopropanecarboxylic acid acts concurrently as a glycine-site agonist and a glutamate-site antagonist at N-methyl-D-aspartate receptors. Mol Pharmacol. 1999 Dec;56(6):1207-18. |[2]Bleecker AB and Kende H. Ethylene: a gaseous signal molecule in plants. Annu Rev Cell Dev Biol. 2000;16:1-18.|[3]Gao, M., Kondo, F., Murakami, T. et al. 1-Aminocyclopropanecarboxylic Acid, an Antagonist of N-Methyl-D-Aspartate Receptors, Causes Hypotensive and Antioxidant Effects with Upregulation of Heme Oxygenase-1 in Stroke-Prone Spontaneously Hypertensive Rats. Hypertens Res, 2007,30, 249–257.
- Research Area:
- Metabolic Disease; Cardiovascular Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store at room temperature 3 years
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Metabolic Enzyme/Protease
