(3S;4S)-PF-06459988
Product Sizes
100 mg
£ POA
HY-19985A-100MG
10 mg
£ POA
HY-19985A-10MG
25 mg
£ POA
HY-19985A-25MG
5 mg
£ POA
HY-19985A-5MG
50 mg
£ POA
HY-19985A-50MG
10mM/1mL
£ POA
HY-19985A-10MM
About this Product
- SKU:
- HY-19985A
- Application:
- Antibody Microarray
- CAS Number:
- 1858291-14-1
- Extra Details:
- (3S; 4S)-PF-06459988 is the S enantiomer of PF-06459988 with less active. PF-06459988 is a potent irreversible inhibitor of T790M mutant epidermal growth factor receptor (EGFR). PF-06459988 has excellent selectivity against EGFR wild-type while possessing a minimally reactive electrophile that reduces the propensity of off-target labeling[1].
- Molecular Weight:
- 431.88
- Purity:
- 98.97
- References:
- [1]Cheng, H., et al. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants. Journal of Medicinal Chemistry, 59(5), 2005–2024.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
