(Z)-4EGI-1
Product Sizes
5 mg
£ POA
HY-19831A-5MG
10 mg
£ POA
HY-19831A-10MG
100 mg
£ POA
HY-19831A-100MG
50 mg
£ POA
HY-19831A-50MG
25 mg
£ POA
HY-19831A-25MG
10mM/1mL
£ POA
HY-19831A-10MM
About this Product
- SKU:
- HY-19831A
- Application:
- Antibody Microarray
- CAS Number:
- 901787-88-0
- Extra Details:
- (Z)-4EGI-1 is the Z-isomer of 4EGI-1 and is an inhibitor of eIF4E/eIF4G interaction and of translation initiation. (Z)-4EGI-1 effectively binds to eIF4E with an IC50 of 43.5 μM and a Kd value of 8.74 μM. (Z)-4EGI-1 has anticancer activity[1][2].
- Molecular Weight:
- 451.28
- Purity:
- 98.0
- References:
- [1]Khuloud Takrouri, et al. Structure-activity Relationship Study of 4EGI-1, Small Molecule eIF4E/eIF4G Protein-Protein Interaction Inhibitors. Eur J Med Chem. 2014 Apr 22;77:361-77.|[2]Poornachandran Mahalingam, et al. Synthesis of Rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) Mimetic and Their in Vitro Characterization as Inhibitors of Protein-Protein Interaction. J Med Chem. 2014 Jun 26;57(12):5094-111.
- Research Area:
- Cancer
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- Cell Cycle/DNA Damage
