(rac)-ZK-304709
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HY-19471-1EACH
About this Product
- SKU:
- HY-19471
- Application:
- Antibody Microarray
- CAS Number:
- 1010440-84-2
- Extra Details:
- (rac)-ZK-304709 is an isoform of ZK-304709 and is an orally active multi-targeted tumor growth inhibitor that inhibits multiple cell cycle-dependent kinases (CDKs); vascular endothelial growth factor receptor kinases (VEGF-RTKs); and platelet-derived growth factor receptor kinase β (PDGF-RTKβ). (rac)-ZK-304709 can dose-dependently inhibit the proliferation and colony formation of neuroendocrine tumor (NET) cells. (rac)-ZK-304709 directly acts on NET cells by inducing G2 cell cycle arrest and apoptosis; while reducing the expression of MCL1; survivin; and HIF1α. (rac)-ZK-304709 effectively controls tumor growth by inducing apoptosis and inhibiting tumor-induced angiogenesis; and may become a potential agent for inhibiting NET[1].
- Molecular Weight:
- 444.96
- References:
- [1]The oral multitarget tumour growth inhibitor, ZK 304709, inhibits growth of pancreatic neuroendocrine tumours in an orthotopic mouse model
- Research Area:
- cancer
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
