(E/Z)-Icerguastat (hydrochloride)
Product Sizes
Get quote
£ POA
HY-18956A-1EACH
About this Product
- SKU:
- HY-18956A
- Additional Names:
- (E/Z)-Sephin1 (hydrochloride); (E/Z)-IFB-088 (hydrochloride)
- CAS Number:
- 32597-86-7
- Extra Details:
- (E/Z)-Icerguastat hydrochloride ((E/Z)-Sephin1 hydrochloride) is a selective inhibitor with activity that prolongs the phosphorylation effects of eIF2α. (E/Z)-Icerguastat hydrochloride protects cells from defects in proteostasis. (E/Z)-Icerguastat hydrochloride was shown to significantly extend the survival of infected prion mice in a mouse model. (E/Z)-Icerguastat hydrochloride effectively reduces PrPSc expression and prion sequence activity in various neuronal cell lines persistently infected with different prion strains[1].
- Molecular Weight:
- 233.10
- References:
- [1]Das I, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015 Apr 10;348(6231):239-42. |[2]Sephin1 Reduces Prion Infection in Prion-Infected Cells and Animal Model
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
