(rel)-Eglumegad
Product Sizes
5 mg
£ POA
HY-18941B-5MG
25 mg
£ POA
HY-18941B-25MG
50 mg
£ POA
HY-18941B-50MG
10 mg
£ POA
HY-18941B-10MG
100 mg
£ POA
HY-18941B-100MG
10mM/1mL
£ POA
HY-18941B-10MM
About this Product
- SKU:
- HY-18941B
- Additional Names:
- (rel)-LY354740; (rel)-Eglumetad
- CAS Number:
- 176027-90-0
- Extra Details:
- (rel)-Eglumegad ((rel)-LY354740) is a relative configuration of Eglumegad (HY-18941). Eglumegad is a highly potent and selective group II (mGlu2/3) receptor agonist with EC50s of 5 and 24 nM for transfected human mGlu2 and mGlu3 receptors; respectively[1].
- Molecular Weight:
- 185.18
- Purity:
- 97.0
- References:
- [1]Boerner T, et al. The group II metabotropic glutamate receptor agonist LY354740 and the D2 receptor antagonist haloperidol reduce locomotor hyperactivity but fail to rescue spatial working memory in GluA1 knockout mice. Eur J Neurosci. 2017 Apr;45(7):912-|[2]Orlando R, et al. Levels of the Rab GDP dissociation inhibitor (GDI) are altered in the prenatal restrain stress mouse model of schizophrenia and are differentially regulated by the mGlu2/3 receptor agonists, LY379268 and LY354740. Neuropharmacology. 2014|[3]Procaccini C, et al. Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. 2013 Oct 10;250:189-200|[4]Lee Y, et al. The mGlu2/3 receptor agonist LY354740 suppresses immobilization stress-induced increase in rat prefrontal cortical BDNF mRNA expression. Neurosci Lett. 2006 May 8;398(3):328-32.
- Research Area:
- Neurological Disease
- Shipping Conditions:
- Ambient
- Storage Conditions:
- -20[o]C; 3 years; 4[o]C; 2 years (Powder)
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Pathway:
- GPCR/G Protein;Neuronal Signaling
